I was asked recently who (in a Web Development context) is good to follow on Twitter. While this is in no way an exhaustive list, this is who I am following and recommend for good quality or interesting tweets.
In no particular order:
@mattb (Matt Biddulph)
@drewm (Drew McLellan)
@zeldman (Jeffrey Zeldman)
@boagworld (Paul Boag)
@plasticbaguk (Tom Coates)
@gruber (John Gruber)
@simplebits (Dan Cederholm)
@shauninman (Shaun Inman)
@adactio (Jeremy Keith)
I should mention that (apparently unlike most people) I read all the tweets that come in on my stream. This means that I am less likely to be following people who, while very relevant are also a wee bit too verbose (for my tastes – your mileage may vary) on topics that I didn’t follow them for! I’m looking at you, @codepo8 (Christian Heilmann)!
Please comment and let me know who I missed…

The issue is that Twitter is not an RSS feed. On my blog you’d never find pointless bollocks about my life or things I am doing right now (unless some of the people listed here) but Twitter is about me, and the web geek is probably 80% of my life, but you need to toughen up to deal with the other 20% if you want to use twitter. Noise is part of the idea.
Apologies if I caused any offence – that was not my intention. I have enjoyed the talks you have given and find what you do interesting and relevant which is why I followed you in the first place…
I guess the way I use Twitter doesn’t fit quite as snugly with the way you use it as it might, but that’s part of what makes Twitter so interesting. No hard feelings I hope!